Methylation & MTHFR genes

The methylation cycle is a chemical process that controls how cells receive the nutrients they need to function. Disruptions in the methylation cycle affect physical health in countless ways. Proper methylation is needed to control inflammation, detox from oxidative stress, maintain DNA, balance mood, control immune function, and improve energy production. Lower methylation contributes to many chronic diseases.

There are at least 40 identified MTHFR gene mutations that affect approximately 1 in 2 people. Some mutations are more severe than others. Supplementing with bioavailable forms of folate (5-MTHF folate), and methyl B12 if necessary, can improve methylation.  A simple genetic test to check for MTHFR gene mutations is available from most doctors. 23andMe.com also offers complete genotyping for $99. The raw data can then be analyzed for methylation errors.

Symptoms of decreased methylation:

  • Adult neurological conditions
  • Aging/wrinkles
  • Allergies
  • Alzheimer’s disease
  • Autism and other spectrum disorders
  • B12 deficiency
  • Brain fog
  • Cardiovascular Disease
  • Cancer
  • Chronic Fatigue Syndrome
  • Decreased muscle tone
  • Diabetes
  • Difficulties with anesthesia
  • Digestive problems
  • Folate deficiency
  • Immune system dysfunction and frequent infections
  • Miscarriages, fertility, and problems in pregnancy
  • Mood and psychiatric disorders
  • Pernicious anemia

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