Most of the population (76%) can remove mold/biotoxins from their body without medical interventions but an estimated 24% have improper immune responses to mold/biotoxins due to specific genetic differences (HLA-DR). In people susceptible to mold/biotoxins, the body’s immune system doesn’t recognize the mold/biotoxins as harmful invaders so it doesn’t form antibodies against them. It can take years for the mold/biotoxins to clear from the body on its own or they can circulate indefinitely until medical interventions remove them and repair the damage they’ve done. Below is the pathways mold/biotoxins take if they aren’t automatically removed from the blood by the liver.
The immune system: Once in the body, the mold/biotoxins bind to surface receptors in nearly every type of cell. This causes constant upregulation of inflammatory pathways, including production of inflammatory cytokines, pathogenic T-cells, and Transforming Growth Factor Beta-1 (TGF-B1). Some patients may develop inappropriate immune responses to certain antibodies such as gliadin (gluten sensitivity), actin (autoimmune hepatitis), anca (ulcerative colitis), cardiolipins (blood clotting), and more. If the immune system becomes chronically activated it can result in high levels of C4a.
Increased cytokines: Excessive cytokines causes the release of MMP-9 in blood which can increase clot formation. In the brain, they can damage leptin receptors in the hypothalamus which inhibits the production of melanocyte stimulating hormone (MSH). White blood cells lose ability to regulate inflammatory cytokines which can slow recovery from other illnesses and infections, restrict blood flow, and lower oxygenation of tissues.
Symptoms of increased cytokines can include: headaches, muscle aches, temperature dysregulation, and difficulty concentrating.
Reduced MSH: MSH is an anti-inflammatory, regulatory hormone produced in the hypothalamus. It controls the production of melatonin, endorphins, leptin, and other hormones. Reduced MSH can cause dysregulation of antidiuretic hormone, thyroid-stimulating hormone, male hormones, ACTH, and cortisol. Lack of MSH can cause malabsorption of nutrients which further weakens the immune system. MSH controls the release of some cytokines; MSH deficiency increases the inflammatory effects of cytokines.
Symptoms of MSH deficiency can include: Sleep issues and non-restorative sleep, chronic fatigue, chronic pain, weight gain that doesn’t respond to exercise or diet, excessive thirst, neurally-mediated hypotension (NMH), low blood volume, frequent urination, increased sensitivity to electrical shocks, nutrient deficiencies, “leaky gut”, increased susceptibility to infections, and slow recovery from infections.